Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis

Polysaccharide capsule and sialic acid-mediated regulation promote biofilm-like intracellular bacterial communities during cystitis. Anderson GG1, Goller CC, Justice S, Hultgren SJ, Seed PC. Author information Abstract Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections (UTIs). A murine UTI model has revealed an infection cascade whereby UPEC undergoes cycles of invasion of...

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An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology

An implementation of next generation sequencing for prevention and diagnosis of urinary tract infection in urology. Mouraviev V1, McDonald M. Author information Abstract INTRODUCTION: The changing face of current infection phenotypes from planktonic to biofilm type has been developed implicating bacterial biofilms in recurrent infection. To date, no specific medical treatment exists to specifically...

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New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms

New Perspectives on the Use of Phytochemicals as an Emergent Strategy to Control Bacterial Infections Including Biofilms. Borges A1,2,3, Abreu AC4,5, Dias C6,7, Saavedra MJ8, Borges F9, Simões M10. Author information Abstract The majority of current infectious diseases are almost untreatable by conventional antibiotic therapy given the advent of multidrug-resistant bacteria. The degree of...

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Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents.

Insights on antimicrobial resistance, biofilms and the use of phytochemicals as new antimicrobial agents. Borges A, Saavedra MJ, Simões M1. Author information Abstract Antimicrobial resistance is one of the most serious public health problems. This is of particular concern when bacteria become resistant to various antimicrobial agents simultaneously and when they form biofilms. Consequently, therapeutic options for the treatment of...

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Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research.

Biofilms and chronic rhinosinusitis: systematic review of evidence, current concepts and directions for research. Harvey RJ1, Lund VJ. Author information Abstract INTRODUCTION: Chronic rhinosinusitis (CRS) possesses the hallmarks of biofilm mediated disease. This paper represents a systematic review of the published evidence for biofilms as the mediator of the inflammation in CRS. Current concepts on biofilm formation and properties, treatment...

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Bacterial Biofilms in Chronic Rhinosinusitis and Their Implications for Clinical Management.

Bacterial Biofilms in Chronic Rhinosinusitis and Their Implications for Clinical Management. Karunasagar A1, Garag SS1, Appannavar SB2, Kulkarni RD2, Naik AS1. Author information Abstract To study the microbiological profile in patients with chronic rhino-sinusitis. To correlate disease severity with the presence of biofilms and host risk factors. To assess outcome of Sinus Surgery 2 weeks post operatively in terms of presence of...

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N-acetylcysteine as powerful molecule to destroy bacterial biofilms. A systematic review.

Abstract OBJECTIVE: Biofilms are microbial communities consisting of bacteria, extremely capable to self-reproduce on biological surfaces, causing infections. Frequently, these biofilms are resistant to classical antibacterial treatments and host immune response. Thus, new adjuvant molecules are mandatory in clinical practice. N-acetylcysteine (NAC), a precursor to the antioxidant glutathione, has...

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